Exhibit
16.1

July
7, 2021
Securities
and Exchange Commission
100
F Street, N.E.
Washington,
DC 20549
We
have read the statements made by Ensysce Biosciences, Inc. (formerly known as Leisure Acquisition Corp.) under Item 4.01 of its
Form 8-K dated July 7, 2021. We agree with the statements concerning our Firm in such Form 8-K; we are not in a position to agree or
disagree with other statements of Ensysce Biosciences, Inc. contained therein.
Very
truly yours, |
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Marcum
LLP |
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