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                          December 23, 2022

       Dr. Lynn Kirkpatrick
       Chief Executive Officer
       Ensysce Biosciences, Inc.
       7946 Ivanhoe Avenue, Suite 201
       La Jolla, California 92037

                                                        Re: Ensysce
Biosciences, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed on December
19, 2022
                                                            File No. 333-268858

       Dear Dr. Lynn Kirkpatrick:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Cindy
Polynice at 202-551-8707 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Eric Kline, Esq.